原标题：EBV相关性肺癌 主张以此术语代替并扩展肺淋巴上皮瘤样癌的安排学谱系
摘要：肺淋巴上皮瘤样癌（lymphoepithelioma-like carcinoma，LELC）是一种罕见的EB病毒（Epstein-Barr virus，EBV）相关性癌。其安排学特征是合体样成长方法伴有显着的淋巴细胞滋润，在安排学上与未分解鼻咽癌无法区别。可是，已有研讨发现，LELC能够表现为非经典形状并缺少明显的淋巴细胞滋润。本研讨中，咱们对61例肺LELC患者进行了体系的临床病理剖析，并运用IHC剖析软件对淋巴细胞滋润进行主动定量剖析。结果表明，肺LELC具有形状学上的连续性，从具有高密度淋巴细胞滋润的经典低分解肿瘤形状，到基本上没有淋巴细胞滋润的非经典形状。这些EBV相关性肿瘤代表了一类特别疾病，一般发生于女人和非吸烟患者。低密度淋巴细胞滋润的肿瘤与非角化性鳞状细胞癌十分类似，一般瘤体较大、在印象学上具有更高的最大标准化摄取值，且复发时间短于具有高密度淋巴细胞滋润的肿瘤。经过详尽的病理查看，咱们观察到一些肺LELC共同的形状学特征，包含肉芽肿性炎、局灶角化、肺泡腔播散及附壁样播散方法。咱们还发现，表现为肉芽肿性炎的肿瘤患者预后较好；可是，是不是真的存在肺泡腔播散与预后没有明显相关性。因为这些“LELC”与未分解鼻咽癌或淋巴上皮癌不同，咱们主张运用另一个术语，EBV相关性肺癌，以包括这一特别疾病的悉数形状谱系。
关键词：淋巴上皮瘤样癌、EB病毒、淋巴细胞、鳞状细胞癌、肺泡腔播散
（Am J Surg Pathol 2019；43：211-219）
美国外科病理学杂志中文版2019年第三期摘要NO.9
( 吴江华 翻译 林冬梅 审校 )
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